Association of Maternal SARS-CoV-2 Infection in Pregnancy with Neonatal Outcomes
Since the start of the COVID-19 pandemic, there has been concern about how to protect vulnerable persons from SARS-CoV-2. In the past, newborn infants experienced increased mortality in pandemics. Knowledge on neonatal outcomes following maternalCOVID-19 in pregnancy is still based on case series and center experiences.
To test the hypothesis that maternal SARS-CoV-2 positivity in pregnancy may be associated with adverse neonatal outcomes, a Swedish nationwide, prospective cohort study was conducted. Maternal age, parity, prepregnancy comorbidity, maternal education, proportions living with a partner, smoking in pregnancy, multiple pregnancy, gestational diabetes, type of delivery onset, and mode of delivery were not significantly different between SARS-CoV-2 positive mothers and mothers without a positive SARS-CoV-2 test result. Type of delivery onset, and mode of delivery were not significantly different between SARS-CoV-2–positive mothers and mothers without a positive SARS-CoV-2 test result. In a nationwide cohort of infants in Sweden, maternal SARSCoV-2 infection in pregnancy was significantly associated with small increases in some neonatal morbidities.
Reference: Norman M, Navér L, Söderling J, Ahlberg M, Askling HH, Aronsson B, Byström E, Jonsson J, Sengpiel V, Ludvigsson JF, Håkansson S. Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes. JAMA. 2021 Apr 29